17α-Methyl-19-norprogesterone

17α-Methyl-19-norprogesterone (also known as 17α-Methyl-19-norP4) is a synthetic steroid and derivative of progesterone, a natural progestogen. It is specifically a derivative of 19-norprogesterone and is also related to 17α-hydroxyprogesterone.

Chemistry

17α-Methyl-19-norprogesterone, as the name implies, is a structural analog of 19-norprogesterone with a methyl group at the 17α position. It is a member of the 17α-alkylated 19-norprogesterone and 17α-hydroxyprogesterone groups of progestins.

Pharmacology

As a progestin, 17α-Methyl-19-norprogesterone has progestogenic activity. It binds to and activates the progesterone receptor (PR), which mediates its effects. The medication has strong progestogenic activity and weak glucocorticoid activity but no other hormonal activity.

History

17α-Methyl-19-norprogesterone was first described in the literature in 1962. It was never marketed for medical use.

See also

• List of progestogens
• List of steroidal antiandrogens

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