2,5-Dimethoxy-4-butylamphetamine

2,5-Dimethoxy-4-butylamphetamine (DOBU) is a psychedelic drug and a member of the DOx family of compounds which are known for their high potency, long duration, and mixture of psychedelic and stimulant effects.

Chemistry[edit | edit source]

DOBU, or 2,5-dimethoxy-4-butylamphetamine, is a molecule of the substituted amphetamine class. Molecules of this class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. DOBU contains methoxy functional groups OCH3 attached to carbons R2 and R5 as well as a butyl chain attached to carbon R4 of the phenyl ring. DOBU belongs to the DOx family of compounds which are named for the substitutions on their amphetamine backbone, and is often reported to have similar effects to its family members such as DOM and DOC.

Pharmacology[edit | edit source]

The mechanism that produces the hallucinogenic and entheogenic effects of DOBU is most likely to result from action as a 5-HT2A receptor agonist in the brain, a mechanism of action shared by various hallucinogenic tryptamine and phenethylamine derivatives.

Effects[edit | edit source]

DOBU is reported to have similar effects to other drugs in the DOx family, which can include open and closed eye visuals, euphoria, change in perception of time, and spiritual experiences. The effects of DOBU are long-lasting, typically persisting for 12 to 24 hours.

Toxicity[edit | edit source]

The toxicity and long-term health effects of recreational DOBU use do not seem to have been studied in any scientific context and the exact toxic dose is unknown.