21-Deoxycortisol
21-Deoxycortisol, also known as 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, is a steroid hormone produced in the adrenal gland. It is a precursor molecule in the production of the hormone cortisol. 21-Deoxycortisol is converted to cortisol by the enzyme 11β-hydroxylase. Deficiency in this enzyme can lead to congenital adrenal hyperplasia, a group of inherited disorders affecting the adrenal glands.
Production and Function[edit | edit source]
21-Deoxycortisol is produced in the adrenal cortex, the outer layer of the adrenal glands. It is synthesized from progesterone through a series of enzymatic reactions. The final step in the production of 21-deoxycortisol is the conversion of 17α-hydroxyprogesterone by the enzyme 21-hydroxylase.
The primary function of 21-deoxycortisol is to serve as a precursor molecule in the production of cortisol, a hormone that plays a crucial role in the body's response to stress. Cortisol also helps regulate metabolism and immune response.
Clinical Significance[edit | edit source]
A deficiency in the enzyme 11β-hydroxylase, which converts 21-deoxycortisol to cortisol, can lead to a form of congenital adrenal hyperplasia (CAH). This is a group of inherited disorders that affect the adrenal glands. Symptoms can include abnormal growth and development, early puberty, and excessive fatigue.
High levels of 21-deoxycortisol can be indicative of 11β-hydroxylase deficiency. This can be diagnosed through a blood test.
See Also[edit | edit source]
References[edit | edit source]
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