4,5-MDO-DMT

4,5-MDO-DMT

4,5-MDO-DMT is a psychedelic and hallucinogenic compound of the tryptamine class. It is structurally related to dimethyltryptamine (DMT), a naturally occurring psychedelic found in various plants and animals, and to 5-MeO-DMT, a potent serotonergic psychedelic.

Chemistry

4,5-MDO-DMT, or 4,5-methylenedioxy-N,N-dimethyltryptamine, is a synthetic compound of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4,5-MDO-DMT is substituted at R4 and R5 of its indole heterocycle with two methylenedioxy functional groups CH2O2. It is further substituted at R1 with a dimethyl group.

Pharmacology

The pharmacology of 4,5-MDO-DMT is not well-studied. However, like other tryptamines, it is thought to act primarily as a 5-HT2A receptor agonist. The 5-HT2A receptor is a subtype of the serotonin receptor that is found in certain areas of the brain and is involved in the mediation of various cognitive and perceptual processes. The activation of this receptor is thought to be responsible for the hallucinogenic effects of 4,5-MDO-DMT.

Effects

The effects of 4,5-MDO-DMT can vary greatly depending on the dose, set, and setting. Common effects reported by users include visual hallucinations, altered thought processes, and a sense of euphoria. Some users also report experiencing a sense of unity or interconnectedness with the universe, a common theme in many psychedelic experiences.

Legal Status

The legal status of 4,5-MDO-DMT varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use. It is always important to be aware of the laws in your jurisdiction before possessing or using any psychedelic substance.

See Also

• Dimethyltryptamine
• 5-MeO-DMT
• Tryptamine
• Psychedelic drug
• Hallucinogen