7,8-Dihydroxyflavone

7,8-Dihydroxyflavone is a naturally-occurring flavone that is found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been proposed as a potent and selective small-molecule agonist of the TrkB receptor, which is associated with neurotrophic activity. This has led to research into its potential therapeutic application in neurodegenerative disorders and neurotrauma.

Chemistry[edit | edit source]

7,8-Dihydroxyflavone is a flavone, a type of phenolic chemical compound. It is a yellow crystalline solid that is soluble in polar organic solvents.

Pharmacology[edit | edit source]

7,8-Dihydroxyflavone mimics the activity of brain-derived neurotrophic factor (BDNF), and has potent neuroprotective properties. It acts as a selective agonist of TrkB, a receptor that is activated by BDNF, and triggers its downstream signaling cascades.

Therapeutic potential[edit | edit source]

Research has suggested that 7,8-Dihydroxyflavone has potential therapeutic applications in a variety of neurodegenerative and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, depression, and schizophrenia. It has also been studied for its potential to promote recovery after neurotrauma.

References[edit | edit source]

7,8-Dihydroxyflavone Resources
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