ANGPTL4
Overview of ANGPTL4[edit | edit source]
ANGPTL4 (Angiopoietin-like 4) is a protein that plays a significant role in lipid metabolism, energy homeostasis, and inflammation. It is a member of the angiopoietin-like protein family, which is known for its involvement in various physiological processes, including angiogenesis, lipid metabolism, and glucose homeostasis.
Structure[edit | edit source]
ANGPTL4 is a glycoprotein that consists of several distinct domains, including a coiled-coil domain and a fibrinogen-like domain. These domains are crucial for its function and interaction with other molecules. The protein is secreted as a full-length molecule and can be cleaved into N-terminal and C-terminal fragments, each having distinct biological activities.
Function[edit | edit source]
ANGPTL4 is primarily involved in the regulation of lipid metabolism. It inhibits the activity of lipoprotein lipase (LPL), an enzyme critical for the hydrolysis of triglycerides in lipoproteins. By inhibiting LPL, ANGPTL4 increases plasma triglyceride levels and influences the distribution of lipids in the body.
In addition to its role in lipid metabolism, ANGPTL4 is also involved in energy homeostasis and inflammation. It is expressed in various tissues, including the liver, adipose tissue, and muscle, and its expression is regulated by nutritional and hormonal signals.
Clinical Significance[edit | edit source]
ANGPTL4 has been implicated in several metabolic disorders, including hyperlipidemia, obesity, and type 2 diabetes. Its role in inhibiting lipoprotein lipase makes it a potential target for therapeutic interventions aimed at lowering plasma triglyceride levels and improving lipid profiles in patients with metabolic syndrome.
Furthermore, ANGPTL4 has been studied for its role in cancer and cardiovascular disease. Its ability to modulate angiogenesis and inflammation suggests that it may have broader implications in disease pathogenesis beyond metabolic disorders.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
