Androstenediol dipropionate

Androstenediol dipropionate is a synthetic androgen and anabolic steroid (AAS) and a derivative of androstenediol (A5-diol), which is a metabolite of dehydroepiandrosterone (DHEA). It is specifically the dipropionate ester of androstenediol, making it a prodrug of androstenediol. Androstenediol dipropionate is used in medicine to treat testosterone deficiencies and has been researched for its potential in osteoporosis treatment. It functions by increasing levels of active androgens in the body, which can then bind to androgen receptors and exert their biological effects.

Medical Uses

Androstenediol dipropionate is primarily used in the treatment of conditions associated with low or absent testosterone levels in men. These conditions can include hypogonadism, delayed puberty, and certain types of impotence. It may also be used in hormone therapy for transgender men during gender transition.

Pharmacology

Mechanism of Action

As a prodrug of androstenediol, androstenediol dipropionate is converted in the body to androstenediol, an androgen that exhibits both anabolic and androgenic effects. Androstenediol itself can further be converted into more potent androgens such as testosterone and estrogens, which mediate the drug's effects in target tissues.

Pharmacokinetics

The dipropionate ester of androstenediol prolongs the duration of action of the drug by slowing its release into the bloodstream. Once administered, enzymes in the blood cleave the ester, releasing active androstenediol.

Adverse Effects

The use of androstenediol dipropionate can lead to a range of adverse effects, similar to those associated with other androgens and anabolic steroids. These can include acne, alopecia (hair loss), voice changes, and increased body hair. In women, it can cause virilization, including deepening of the voice and clitoral enlargement. Long-term use can also lead to liver damage and increased risk of cardiovascular diseases.

Legal Status

The legal status of androstenediol dipropionate varies by country. In some jurisdictions, it is classified as a controlled substance, which restricts its use and distribution. Athletes should be aware that its use may be prohibited by anti-doping agencies.

See Also

• Anabolic steroid
• Androgen
• Ester
• Prodrug

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