Anecortave acetate

Anecortave Acetate is a synthetic derivative of cortisol, a steroid hormone produced by the adrenal glands. It is primarily used in the treatment of age-related macular degeneration (AMD), a common eye condition and a leading cause of vision loss among people age 50 and older.

Etymology

The term "Anecortave Acetate" is derived from the words "anecortave", which is a synthetic derivative of cortisol, and "acetate", which refers to the acetate ester that is added to the molecule to increase its solubility and stability.

Pharmacology

Anecortave Acetate works by inhibiting the growth of new blood vessels (angiogenesis) in the retina, a process that is often associated with the progression of AMD. It is believed to do this by inhibiting the action of vascular endothelial growth factor (VEGF), a protein that stimulates angiogenesis.

Clinical Use

Anecortave Acetate is administered by sub-Tenon's capsule injection, a procedure in which the drug is injected into the space located behind the eye. This method of administration allows the drug to be delivered directly to the retina, thereby maximizing its therapeutic effect while minimizing systemic side effects.

Side Effects

The most common side effects of Anecortave Acetate include temporary vision changes, eye pain, and conjunctival hyperemia (redness of the eye). Less common side effects include cataract formation, increased intraocular pressure, and retinal detachment.

Related Terms

• Cortisol: A steroid hormone produced by the adrenal glands. It is involved in a wide range of physiological processes, including the body's response to stress.
• Age-related macular degeneration: A common eye condition and a leading cause of vision loss among people age 50 and older. It is characterized by damage to the macula, a small area in the center of the retina that is responsible for sharp, central vision.
• Vascular endothelial growth factor: A protein that stimulates the growth of new blood vessels. It is often upregulated in conditions that involve abnormal angiogenesis, such as AMD.

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