Autoimmune gastrointestinal dysmotility

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Autoimmune gastrointestinal dysmotility
Synonyms AGID
Pronounce N/A
Specialty N/A
Symptoms Nausea, vomiting, abdominal pain, bloating, constipation, diarrhea
Complications Malnutrition, dehydration, intestinal obstruction
Onset Variable
Duration Chronic
Types N/A
Causes Autoimmune disease
Risks Autoimmune disorders, genetic predisposition
Diagnosis Clinical evaluation, antibody testing, gastrointestinal motility studies
Differential diagnosis Irritable bowel syndrome, gastroparesis, chronic intestinal pseudo-obstruction
Prevention N/A
Treatment Immunosuppressive therapy, prokinetic agents, dietary modifications
Medication Corticosteroids, immunomodulators, antiemetics
Prognosis Variable, depends on response to treatment
Frequency Rare
Deaths N/A


A disorder affecting gastrointestinal motility due to autoimmune causes


Autoimmune gastrointestinal dysmotility (AGID) is a rare disorder characterized by abnormal movement of the muscles in the gastrointestinal tract due to an autoimmune response. This condition can affect any part of the gastrointestinal tract, leading to a variety of symptoms and complications.

Pathophysiology[edit | edit source]

AGID occurs when the body's immune system mistakenly attacks the nerves and muscles of the gastrointestinal tract. This autoimmune attack can lead to inflammation and damage to the enteric nervous system, which is responsible for controlling the motility of the gastrointestinal tract. The resulting dysmotility can cause either slowed or uncoordinated movement of the digestive tract, affecting the normal process of digestion and absorption.

Symptoms[edit | edit source]

The symptoms of AGID can vary widely depending on which part of the gastrointestinal tract is affected. Common symptoms include:

These symptoms can lead to significant discomfort and may severely impact a patient's quality of life.

Diagnosis[edit | edit source]

Diagnosing AGID can be challenging due to its rarity and the overlap of symptoms with other gastrointestinal disorders. A comprehensive evaluation typically includes:

Treatment[edit | edit source]

Treatment of AGID focuses on managing symptoms and addressing the underlying autoimmune process. Therapeutic approaches may include:

Prognosis[edit | edit source]

The prognosis for individuals with AGID varies depending on the severity of the condition and the response to treatment. Early diagnosis and appropriate management can improve outcomes and quality of life for many patients.

Related pages[edit | edit source]

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Contributors: Prab R. Tumpati, MD