Autoimmune oophoritis
Autoimmune oophoritis is a rare autoimmune disease where the body's immune system mistakenly attacks the ovaries.[1] This causes the ovaries to have inflammation, atrophy and fibrosis. The changes to the ovaries can cause them to not function properly.
Signs and symptoms[edit | edit source]
- Primary amenorrhea – where menstruation has never occurred
- Secondary amenorrhea – where menstruation occurred once puberty happened but then later stopped
- Infertility
- Sex hormone deficiency
- Lower abdominal pain
- Fever
- Malaise
- Vaginal discharge
- Irregular bleeding or absent menstrual period – also known as amenorrhea
- Symptoms that are related to cysts
Causes[edit | edit source]
The underlying cause of autoimmune oophoritis is unknown. In many cases it can be a part of lupus, pernicious anemia, myasthenia gravis, or other autoimmune conditions. Autoimmune oophoritis can be associated with autoimmune polyglandular syndrome type I and type II.[2]
Diagnoses[edit | edit source]
Diagnosis involves a special blood test which looks for anti-steroid or anti-ovarian antibodies, a pelvic ultrasound to look for enlarged cystic ovaries, and other type of tests to rule out other issues that can be a part of primary ovarian insufficiency (POI).[2]
References[edit | edit source]
This article incorporates public domain material from websites or documents of the National Institutes of Health.
External links[edit | edit source]
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