Bone marrow-derived macrophage

Bone marrow-derived macrophages (BMDMs) are a type of immune cell that originate from bone marrow stem cells. They are part of the mononuclear phagocyte system, which includes other types of macrophages and dendritic cells. BMDMs play a crucial role in the body's immune response, helping to fight off infections and diseases.

Function

BMDMs function as part of the body's immune system, helping to protect the body from harmful pathogens. They do this by engulfing and destroying foreign substances, such as bacteria and viruses, in a process known as phagocytosis. In addition to their role in immune defense, BMDMs also play a role in tissue repair and inflammation.

Development

BMDMs develop from hematopoietic stem cells in the bone marrow. These stem cells differentiate into monocytes, which then leave the bone marrow and enter the bloodstream. Once in the tissues, these monocytes can further differentiate into macrophages.

Role in Disease

BMDMs have been implicated in a number of diseases, including cancer, autoimmune diseases, and infectious diseases. In cancer, BMDMs can promote tumor growth and metastasis. In autoimmune diseases, they can contribute to inflammation and tissue damage. In infectious diseases, they can either help to fight off the infection or, in some cases, be exploited by the pathogen to promote its own survival.

Research

Research into BMDMs is ongoing, with scientists seeking to better understand their role in health and disease. This research could potentially lead to new treatments for a variety of conditions, from cancer to autoimmune diseases.

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