Bradykinin receptor B2

Bradykinin receptor B2 is a protein that in humans is encoded by the BDKRB2 gene. This receptor is a member of the G protein-coupled receptor superfamily. It is specifically activated by the biomolecule bradykinin, and thus is implicated in a variety of pathophysiological processes.

Structure

The Bradykinin receptor B2 is a transmembrane protein that spans the cell membrane seven times. It is approximately 41 kDa in size and is composed of 364 amino acid residues. The receptor's structure allows it to interact with G proteins inside the cell once it has been activated by bradykinin on the outside of the cell.

Function

The primary function of the Bradykinin receptor B2 is to mediate the effects of bradykinin, a potent vasodilator. When bradykinin binds to the receptor, it triggers a cascade of intracellular events, including the activation of phospholipase C and the release of calcium ions from intracellular stores. This leads to a variety of physiological responses, including vasodilation, inflammation, and pain perception.

Clinical significance

Alterations in the function of the Bradykinin receptor B2 have been implicated in a variety of medical conditions. For example, mutations in the BDKRB2 gene have been associated with hypertension. Additionally, the receptor has been found to play a role in the progression of certain types of cancer, as well as in the response to injury and infection.

See also

• Bradykinin receptor B1
• G protein-coupled receptor
• Bradykinin

References

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