Bradykinin receptor B1

Bradykinin receptor B1 is a protein that in humans is encoded by the BDKRB1 gene. It is a member of the G protein-coupled receptor family. The Bradykinin receptor B1 is a receptor for bradykinin. The receptor is coupled to G proteins that stimulate a phosphatidylinositol-calcium second messenger system.

Function

The Bradykinin receptor B1 is part of the kinin-kallikrein system which is involved in inflammation, pain, and other processes. Bradykinin, a 9 amino acid peptide, is a potent vasodilator that increases capillary permeability, stimulates the release of prostaglandins, causes smooth muscle contraction, and induces pain. The B1 receptor is expressed only after tissue injury or inflammation, and its signaling may contribute to inflammation and pain.

Clinical significance

The Bradykinin receptor B1 has been implicated in a variety of disease states, including diabetes, inflammation, and cancer. In diabetes, the receptor is upregulated and contributes to the vascular complications of the disease. In inflammation, the receptor is induced and contributes to the inflammatory response. In cancer, the receptor is overexpressed in certain types of tumors and may contribute to tumor growth and metastasis.

See also

• Bradykinin receptor
• Bradykinin receptor B2
• G protein-coupled receptor
• Kinin-kallikrein system