MODY 1

MODY 1 is a form of Maturity onset diabetes of the young (MODY), a group of inherited forms of diabetes mellitus. MODY 1 is caused by mutations in the HNF4A gene.

Overview

MODY 1 is a rare form of diabetes that is different from both Type 1 diabetes and Type 2 diabetes. It is caused by a mutation in a single gene and is inherited in an autosomal dominant manner. This means that a person only needs to inherit one copy of the mutated gene from one parent to develop the disease.

Symptoms

The symptoms of MODY 1 are similar to those of other forms of diabetes. They include frequent urination, excessive thirst, fatigue, blurred vision, and weight loss. However, because MODY 1 is a form of monogenic diabetes, it often presents at a younger age than type 2 diabetes and may be misdiagnosed as type 1 diabetes.

Diagnosis

Diagnosis of MODY 1 involves genetic testing to identify the presence of a mutation in the HNF4A gene. This is usually done through a blood test. It is important to correctly diagnose MODY 1 as it can have implications for treatment and for other family members who may also be at risk.

Treatment

Treatment for MODY 1 typically involves lifestyle changes such as diet and exercise, and may also include medication. Unlike type 1 diabetes, people with MODY 1 do not always require insulin therapy.

See also

• Maturity onset diabetes of the young
• Diabetes mellitus
• HNF4A

MODY 1 Resources
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