MODY 3
MODY 3 | |
---|---|
Synonyms | Maturity onset diabetes of the young type 3 |
Pronounce | N/A |
Specialty | N/A |
Symptoms | Hyperglycemia, polyuria, polydipsia, weight loss |
Complications | Diabetic retinopathy, nephropathy, neuropathy |
Onset | Typically in adolescence or early adulthood |
Duration | Chronic |
Types | N/A |
Causes | Genetic mutation in the HNF1A gene |
Risks | Family history of diabetes |
Diagnosis | Genetic testing, blood glucose tests |
Differential diagnosis | Type 1 diabetes, Type 2 diabetes |
Prevention | N/A |
Treatment | Dietary management, oral hypoglycemic agents |
Medication | Sulfonylureas, insulin (if necessary) |
Prognosis | Variable, depending on management |
Frequency | Accounts for 1-2% of all diabetes cases |
Deaths | N/A |
MODY 3 is a form of Maturity onset diabetes of the young (MODY), which is a group of inherited forms of diabetes mellitus. It is caused by mutations in the HNF1A gene.
Overview[edit | edit source]
MODY 3 is the most common form of MODY. It is characterized by an onset usually before the age of 25, a primary defect in insulin secretion and a strong inheritance pattern. The disease is caused by mutations in the HNF1A gene, which encodes a transcription factor that regulates the expression of several liver-specific genes.
Symptoms[edit | edit source]
The symptoms of MODY 3 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, blurred vision, and weight loss. However, MODY 3 often goes undiagnosed because the symptoms are mild or absent.
Diagnosis[edit | edit source]
The diagnosis of MODY 3 is based on clinical features and genetic testing. The presence of diabetes in multiple generations, the onset of diabetes at a young age, and the absence of obesity or other risk factors for type 2 diabetes suggest the diagnosis of MODY 3.
Treatment[edit | edit source]
The treatment of MODY 3 involves lifestyle modifications and medication. Patients with MODY 3 often respond well to low doses of sulfonylureas, which stimulate the release of insulin from the pancreas.
Prognosis[edit | edit source]
The prognosis of MODY 3 is generally good, but patients are at risk for long-term complications of diabetes, including heart disease, kidney disease, and eye disease.
See also[edit | edit source]
References[edit | edit source]
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