CAMKK2

CAMKK2 or Calcium/Calmodulin Dependent Protein Kinase Kinase 2 is a protein that in humans is encoded by the CAMKK2 gene. It is a part of the serine/threonine-specific protein kinase family, which is involved in the transduction of intracellular calcium signals.

Function

CAMKK2 is a calcium/calmodulin-dependent protein kinase that plays a role in a wide range of biological processes by phosphorylating a variety of protein substrates. The process of phosphorylation is crucial in transmitting signals within cells and regulating cellular activity.

Structure

The CAMKK2 protein is composed of 501 amino acids and has a molecular weight of approximately 57 kDa. It contains a protein kinase domain, a calmodulin-binding domain, and an autoinhibitory domain.

Clinical Significance

Alterations in the CAMKK2 gene have been associated with various diseases. For instance, mutations in this gene have been linked to obesity and type 2 diabetes. In addition, CAMKK2 has been implicated in the progression of several types of cancer, including prostate cancer and breast cancer.

Research

Research into CAMKK2 has been extensive, with studies focusing on its role in metabolic diseases, neurological disorders, and cancer. Understanding the function of CAMKK2 could lead to the development of new therapeutic strategies for these conditions.

See Also

• Calcium/Calmodulin Dependent Protein Kinase Kinase 1
• Calcium signaling
• Protein kinase

References

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