CRTC1

CRTC1 (CREB-regulated transcription coactivator 1) is a protein that in humans is encoded by the CRTC1 gene. It is a member of the CREB (cAMP response element-binding protein) regulated transcription coactivator family. This protein has been shown to interact with and augment the activity of adenylate cyclase and cAMP/protein kinase A pathway that mediates signal-dependent activation of CREB.

Function

CRTC1 is a transcriptional coactivator that regulates the genes involved in energy homeostasis, somatic growth, and adipogenesis. It is also involved in the regulation of long-term memory and synaptic plasticity in the hippocampus. CRTC1 is phosphorylated by AMP-activated protein kinase (AMPK) and is thus regulated by cellular energy status.

Clinical significance

Mutations in the CRTC1 gene have been associated with Sotos syndrome, a genetic condition causing physical overgrowth during the first years of life. CRTC1 has also been implicated in the development of cancer, particularly lung cancer and endometrial cancer.

Interactions

CRTC1 has been shown to interact with:

• CREB
• TORC2
• 14-3-3 protein

See also

• CREB
• CRTC2
• CRTC3

External links

• NCBI Gene
• UniProt