Chemotherapy-induced acral erythema

From WikiMD's Wellnesspedia

Chemotherapy-induced acral erythema (CIAE), also known as hand-foot syndrome or palmar-plantar erythrodysesthesia, is a skin condition that occurs as a side effect of certain chemotherapy drugs. It is characterized by redness, swelling, and pain in the palms of the hands and the soles of the feet.

Symptoms[edit | edit source]

File:Chemotherapy-induced acral erythema.jpg
Chemotherapy-induced acral erythema on a patient's hand

The symptoms of CIAE typically appear within the first few weeks of starting chemotherapy treatment. They include:

  • Redness and swelling in the palms and soles
  • Pain and sensitivity in the affected areas
  • Blisters and peeling skin
  • Difficulty walking or using the hands due to pain and swelling

Causes[edit | edit source]

CIAE is caused by certain chemotherapy drugs, including doxorubicin, cytarabine, and fluorouracil. These drugs can damage the small blood vessels in the hands and feet, leading to the symptoms of CIAE. The exact mechanism of this damage is not fully understood.

Treatment[edit | edit source]

Treatment for CIAE focuses on relieving symptoms and preventing further damage. This may include:

  • Topical creams to soothe the skin
  • Pain relievers
  • Cold compresses to reduce swelling
  • Avoiding activities that put pressure on the hands and feet

In severe cases, the chemotherapy dosage may need to be reduced or the treatment schedule altered.

Prevention[edit | edit source]

Prevention strategies for CIAE include:

  • Using gloves and socks to protect the hands and feet
  • Avoiding hot water and harsh soaps
  • Keeping the skin moisturized
  • Avoiding activities that put pressure on the hands and feet

See also[edit | edit source]

Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Prab R. Tumpati, MD