Erythromelalgia
Erythromelalgia[edit | edit source]
Erythromelalgia, formerly known as Mitchell's disease (named after Silas Weir Mitchell), is a rare vascular peripheral pain disorder. This condition leads to the episodic blocking of blood vessels, typically in the lower extremities or hands, which subsequently become inflamed and hyperemic.
Definition[edit | edit source]
Erythromelalgia is a disorder characterized by:
- Intense burning pain.
- Redness (erythema).
- Increased temperature in the affected areas.
- Episodes of symptom exacerbation and relief.
History[edit | edit source]
The condition was first described by Dr. Silas Weir Mitchell in the 19th century, hence the former name Mitchell's disease.
Pathophysiology[edit | edit source]
The exact cause of erythromelalgia remains unclear, but it is believed to result from:
- Abnormalities in the normal vasomotor responses or functioning of the blood vessels.
- Possible genetic mutations in some cases.
Symptoms[edit | edit source]
Main symptoms include:
- Intense burning or throbbing pain.
- Swelling or inflammation of the affected region.
- Increased warmth and redness in the affected areas.
- Episodes that may last from minutes to hours or even longer.
Diagnosis[edit | edit source]
Diagnosis is primarily clinical, based on:
- Detailed medical history.
- Physical examination.
- Exclusion of other conditions.
In some cases, a skin biopsy or other tests might be performed to rule out other disorders.
Treatment[edit | edit source]
There is no definitive cure for erythromelalgia, but treatments aim to relieve symptoms. Common approaches include:
- Cooling the affected area.
- Avoiding triggers such as heat or specific activities.
- Pain relievers like NSAIDs or aspirin.
- Topical creams or patches.
- Certain anticonvulsants or antidepressants.
Epidemiology[edit | edit source]
Erythromelalgia is a rare condition, with a variable reported incidence. It can affect people of all ages but may be more common in certain age groups.
See Also[edit | edit source]
Footnotes[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
