Ciclotizolam

A benzodiazepine derivative

Ciclotizolam
File:Ciclotizolam structure.png
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CAS Number	52042-50-3
PubChem	71771
DrugBank
ChemSpider	64800
KEGG	D07795

Ciclotizolam is a benzodiazepine derivative that is used for its anxiolytic, hypnotic, and sedative properties. It is a member of the triazolobenzodiazepine class, which is characterized by the fusion of a triazole ring to the benzodiazepine structure.

Chemical Structure

Ciclotizolam has the chemical formula C₁₇H₁₂Cl₂N₄. The structure includes a triazole ring fused to the benzodiazepine core, with a chlorine atom at the 8-position and a 2-chlorophenyl group at the 6-position. This structure is responsible for its pharmacological activity.

Pharmacology

Ciclotizolam acts on the central nervous system by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor. This action results in increased inhibitory neurotransmission, leading to its sedative and anxiolytic effects. Like other benzodiazepines, it is thought to increase the frequency of chloride channel opening events, which hyperpolarizes the neuron and makes it less excitable.

Uses

Ciclotizolam is primarily used for its sedative and anxiolytic effects. It is prescribed for the short-term treatment of insomnia and for the management of anxiety disorders. Due to its potential for tolerance, dependence, and withdrawal, it is generally recommended for short-term use only.

Side Effects

Common side effects of ciclotizolam include drowsiness, dizziness, and fatigue. More serious side effects can include respiratory depression, confusion, and impaired coordination. Long-term use can lead to tolerance and dependence, and abrupt discontinuation can result in withdrawal symptoms.

Legal Status

The legal status of ciclotizolam varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and dependence. It is important for prescribers to be aware of the legal regulations in their area.

Related Compounds

Ciclotizolam is related to other triazolobenzodiazepines such as alprazolam and triazolam. These compounds share similar pharmacological properties and are used for similar therapeutic purposes.

Related Pages

• Benzodiazepine
• Triazolobenzodiazepine
• Anxiolytic
• Hypnotic
• Sedative