From WikiMD's Food, Medicine & Wellnesspedia

What is Crizanlizumab-tmca?[edit | edit source]

What are the uses of this medicine?[edit | edit source]

  • Crizanlizumab (Adakveo) is a prescription medicine used in people 16 years of age and older who have sickle cell disease to help reduce how often painful crises happen.

How does this medicine work?[edit | edit source]

  • A humanized monoclonal immunoglobulin G1 anti-P-selectin antibody with vaso-protective and anti-vaso-occlusive properties.
  • Upon administration, crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand-1 (PSGL-1; SELPLG) on neutrophils and monocytes.
  • P-selectin, a glycoprotein that functions as a cell adhesion molecule (CAM), translocates to the surface of activated endothelial cells and platelets, upon stimulation, where it binds to its ligand and mediates the rolling of platelets and neutrophils on activated endothelial cells.
  • Therefore, blockade of p-selectin may inhibit platelet aggregation, maintain blood flow and minimize sickle cell-related pain crises (SCPC).

Who Should Not Use this medicine?[edit | edit source]

  • This medicine have no usage limitations.

Is this medicine FDA approved?[edit | edit source]

  • The U.S. Food and Drug Administration (FDA) approved crizanlizumab

How should this medicine be used?[edit | edit source]

  • should be prepared and administered by a healthcare professional.
  • Administer Adakveo diluted solution by intravenous infusion over a period of 30 minutes through an intravenous line, which must contain a sterile, nonpyrogenic 0.2 micron inline filter.
  • No incompatibilities have been observed between Adakveo and infusion sets composed of PVC, polyethylene (PE-lined PVC), polyurethane (PU), and in-line filter membranes composed of polyethersulfone (PES, neutral and positively charged), positively charged polyamide (PA), and polysulphone (PSU).
  • Do not mix or coadminister with other drugs through the same intravenous line.
  • After administration of Adakveo, flush the line with at least 25 mL of 0.9% Sodium Chloride or 5% Dextrose Injection.

What are the dosage forms and brand names of this medicine?[edit | edit source]

  • Brand name: Adakveo
  • Injection: 100 mg/10 mL (10 mg/mL) as a clear to opalescent, colorless to slightly brownish-yellow solution in a single-dose vial.
  • Administer Adakveo 5 mg/kg by intravenous infusion over a period of 30 minutes at Week 0, Week 2, and every 4 weeks thereafter.

What should i do if i miss a dose?[edit | edit source]

  • consult your doctor and inform them

For health care professionals:

  • If a dose is missed, administer Adakveo as soon as possible.
  • If Adakveo is administered within 2 weeks after the missed dose, continue dosing according to the patient's original schedule.
  • If Adakveo is administered more than 2 weeks after the missed dose, continue dosing every 4 weeks thereafter.
  • Adakveo may be given with or without hydroxyurea.

What side effects can this medication cause?[edit | edit source]

What special precautions should I follow?[edit | edit source]

What to do in case of emergency/overdose?[edit | edit source]

  • Since crizanlizumab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur

Can this medicine be used in pregnancy?[edit | edit source]

  • Based on data from animal studies, Adakveo has the potential to cause fetal harm when administered to a pregnant woman
  • Adakveo should only be used during pregnancy if the expected benefit to the patient justifies the potential risk to the fetus

Can this medicine be used in children?[edit | edit source]

  • can be used in children above 16 years
  • safety and efficacy below 16 years is not been established

What should I know about storage and disposal of this medication?[edit | edit source]

  • The single-dose vial has a rubber stopper and an aluminum cap with a plastic flip-off disk. Each 10 mL vial is made of Type 1 glass.
  • Store and transport refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.
  • Do not shake. Do not freeze.
Crizanlizumab-tmca Resources
Doctor showing form.jpg

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski

Crizanlizumab-tmca Resources
Doctor showing form.jpg

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.