D2-like

D2-like receptor is a family of G protein-coupled receptors that are targeted by various drugs used to treat schizophrenia and Parkinson's disease. The D2-like receptor family includes D2, D3, and D4 receptors.

Function

D2-like receptors are inhibitory G protein-coupled receptors. They inhibit adenylyl cyclase activity, reducing levels of cyclic adenosine monophosphate (cAMP) within cells. This inhibition of cAMP is achieved via the action of G proteins.

Clinical significance

D2-like receptors are the target of various drugs used to treat schizophrenia and Parkinson's disease. Antipsychotic drugs, such as chlorpromazine and haloperidol, are often D2 receptor antagonists.

See also

• Dopamine receptor
• D1-like receptor
• G protein-coupled receptor

References

D2-like Resources
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