David M. Holtzman

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David M. Holtzman is a prominent American neurologist and neuroscientist known for his extensive research on Alzheimer's disease and other neurodegenerative disorders. He is a professor and former chair of the Department of Neurology at Washington University in St. Louis.

Early Life and Education

David M. Holtzman was born in City, State. He completed his undergraduate studies at University where he earned a degree in Field of Study. He then attended Medical School where he obtained his M.D. degree. Following medical school, Holtzman completed his residency in neurology at Institution and a fellowship in neurobiology at Institution.

Career

Holtzman began his academic career at Washington University in St. Louis where he has held various positions, including professor of neurology and head of the Department of Neurology. His research primarily focuses on the mechanisms underlying Alzheimer's disease and other neurodegenerative diseases.

Research Contributions

Holtzman has made significant contributions to the understanding of Alzheimer's disease, particularly in the areas of amyloid-beta metabolism, tau protein pathology, and the role of apolipoprotein E (ApoE) in disease progression. His work has led to the development of potential therapeutic strategies aimed at slowing or preventing the progression of Alzheimer's disease.

Amyloid-beta Metabolism

Holtzman's research has elucidated the processes involved in the production, clearance, and aggregation of amyloid-beta peptides, which are central to the pathogenesis of Alzheimer's disease. He has identified key enzymes and pathways that regulate amyloid-beta levels in the brain.

Tau Protein Pathology

In addition to his work on amyloid-beta, Holtzman has investigated the role of tau protein in neurodegenerative diseases. His studies have shown how abnormal tau phosphorylation and aggregation contribute to neuronal dysfunction and neurodegeneration.

Apolipoprotein E (ApoE)

Holtzman has also explored the impact of different apolipoprotein E (ApoE) isoforms on Alzheimer's disease risk and progression. His research has demonstrated that ApoE4, a major genetic risk factor for Alzheimer's disease, influences amyloid-beta deposition and tau pathology.

Awards and Honors

Throughout his career, Holtzman has received numerous awards and honors for his contributions to neurology and neuroscience. These include the MetLife Foundation Award for Medical Research in Alzheimer's Disease, the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, and election to the National Academy of Medicine.

Personal Life

Holtzman resides in City, State with his family. He is married to Spouse's Name and has number children.

See Also

• Alzheimer's disease
• Neurodegenerative disease
• Amyloid-beta
• Tau protein
• Apolipoprotein E