Dimethyltrienolone

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Dimethyltrienolone is a synthetic androgen and anabolic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was never marketed. It is one of the most potent AAS to have ever been synthesized, with reportedly the highest ratio of anabolic to androgenic activity of any AAS.

Chemistry[edit | edit source]

Dimethyltrienolone, also known as 7α,17α-dimethyl-19-nortestosterone or as 7α,17α-dimethylestr-4-en-17β-ol-3-one, is a synthetic estrane steroid and a 17α-alkylated derivative of nandrolone.

Pharmacology[edit | edit source]

As an AAS, dimethyltrienolone is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women.

Side effects[edit | edit source]

Potential side effects of dimethyltrienolone include virilization and hepatotoxicity among others. As with all AAS, it can also have negative effects on cardiovascular health, including lipid profile changes and hypertension.

History[edit | edit source]

Dimethyltrienolone was first described in the literature in 1967. It was found to have the highest ratio of anabolic to androgenic effects of any steroid yet discovered, but was never marketed due to concerns about its potential for side effects.

See also[edit | edit source]

Resources[edit source]

Latest articles - Dimethyltrienolone

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Contributors: Prab R. Tumpati, MD