Diphenadione

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Diphenadione is a vitamin K antagonist and an anticoagulant, which is often used as a rodenticide. It is a second-generation derivative in the family of coumarin-based anticoagulants. Diphenadione was first registered in the United States in 1953.

Mechanism of Action[edit | edit source]

Diphenadione exerts its anticoagulant properties by inhibiting the vitamin K epoxide reductase enzyme. This enzyme is responsible for the recycling of vitamin K in the body. By inhibiting this enzyme, Diphenadione disrupts the blood clotting process, leading to uncontrolled bleeding and eventual death in rodents.

Uses[edit | edit source]

Diphenadione is primarily used as a rodenticide. It is effective against a variety of rodents including rats, mice, and squirrels. It is often used in situations where first-generation anticoagulants have failed due to resistance.

Toxicity[edit | edit source]

Diphenadione is highly toxic to mammals and birds, and slightly toxic to fish and aquatic invertebrates. It is classified as a Category C, possible human carcinogen. Exposure to Diphenadione can lead to a variety of symptoms including nausea, vomiting, abdominal pain, and bleeding.

Treatment[edit | edit source]

Treatment for Diphenadione poisoning involves discontinuing exposure to the substance and administering vitamin K1 therapy. In severe cases, blood transfusion may be necessary.

See Also[edit | edit source]

References[edit | edit source]

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