Distal intestinal obstruction syndrome

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Distal Intestinal Obstruction Syndrome (DIOS) is a medical condition primarily affecting individuals with Cystic Fibrosis (CF). It is characterized by partial or complete obstruction of the intestines due to thickened intestinal contents. DIOS is considered a complication of CF, a genetic disorder that affects various organs, especially the lungs and digestive system.

Causes and Pathophysiology[edit | edit source]

DIOS results from the accumulation of thick, sticky mucus in the intestines, a hallmark of Cystic Fibrosis. This mucus buildup is due to the defective function of the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) protein, which leads to abnormal transport of chloride and sodium across cell membranes, causing the mucus to be dehydrated and viscous. In the intestines, this thick mucus can mix with fecal matter, leading to obstruction, primarily in the ileocecal region.

Symptoms[edit | edit source]

The symptoms of DIOS can vary but typically include abdominal pain, bloating, nausea, and the inability to pass stools or gas. In severe cases, it may lead to complete intestinal blockage, which is a medical emergency.

Diagnosis[edit | edit source]

Diagnosis of DIOS involves a combination of clinical assessment and imaging studies. A detailed medical history and physical examination are crucial. Imaging techniques such as abdominal X-rays or ultrasound can help visualize the obstruction. In some cases, a contrast enema may be used for a more detailed assessment.

Treatment[edit | edit source]

The treatment of DIOS focuses on relieving the obstruction and preventing future episodes. Initial management often includes oral rehydration solutions and laxatives to soften the intestinal contents. In more severe cases, enemas may be required. Gastrointestinal surgery is considered only in cases where conservative management fails. Long-term management may involve dietary modifications, pancreatic enzyme supplementation, and medications to improve intestinal motility.

Prevention[edit | edit source]

Preventive measures for DIOS include maintaining adequate hydration, a high-fiber diet, and regular use of pancreatic enzymes as prescribed for individuals with CF. Regular follow-up with a healthcare provider specializing in CF is essential to monitor and manage potential complications.

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Contributors: Prab R. Tumpati, MD