Doxepin
(Redirected from Doxepin hydrochloride)
Information about Doxepin[edit source]
Doxepin is a tricyclic antidepressant that widely used in the therapy of depression.
Liver safety of Doxepin[edit source]
Doxepin can cause mild and transient serum enzyme elevations but is a rare cause of clinically apparent acute cholestatic liver injury.
Mechanism of action of Doxepin[edit source]
Doxepin (dox' e pin) is a dibenzoxepine derived tricyclic antidepressant which acts by inhibition of serotonin and norepinephrine reuptake within synaptic clefts in the central nervous system, thus increasing brain levels of these neurotransmitters.
FDA approval information for Doxepin[edit source]
Doxepin is indicated for therapy of depression or anxiety and was approved for this indication in the United States in 1969 and it is still widely used, with more than 2 million prescriptions being filled yearly.
Dosage and administration for Doxepin[edit source]
Doxepin is available in generic forms and under the brand names of Sinequan in capsules of 10, 25, 50, 75, 100 and 150 mg as well as an oral solution. The recommended adult dose for depression is 25 to 75 mg daily in divided doses, increasing gradually to a maximum of 300 mg daily. Doxepin can also be given as a single nighttime dose (maximum dose of 150 mg).
Side effects of Doxepin[edit source]
Common side effects include dizziness, headache, drowsiness, restlessness, confusion, gastrointestinal upset, nausea, increased appetite, weight gain, blurred vision, dry mouth, urinary retention, rash and hypersensitivity reactions. Rare but potentially severe adverse events include suicidal thoughts and behaviors and acute glaucoma.
The following are antidepressant subclasses and drugs
MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine
SNRIs Duloxetine, Levomilnacipran, Venlafaxine
SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine
Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine
Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone
2D structure of Doxepin
Ball-and-stick model of Doxepin
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
