EN2 (gene)

EN2 (Engrailed-2) is a gene that in humans is encoded by the EN2 locus. It is a member of the engrailed homeobox family and is involved in the regulation of pattern formation during neurogenesis.

Function

The EN2 gene is a homeobox gene, a class of genes that play a crucial role in morphogenesis. It is expressed in the developing nervous system, particularly in the midbrain and cerebellum. The protein encoded by this gene is a transcription factor that is thought to regulate the expression of other genes involved in neural development.

Clinical significance

Alterations in the EN2 gene have been associated with a number of neurodevelopmental disorders, including autism and schizophrenia. Studies have shown that certain genetic variants of EN2 may increase the risk of autism, although the exact mechanism is not yet understood.

Research

Research into the EN2 gene is ongoing, with scientists seeking to understand its role in neural development and its potential involvement in neurodevelopmental disorders. This research could potentially lead to new treatments for conditions such as autism and schizophrenia.

See also

• Homeobox
• Neurogenesis
• Autism
• Schizophrenia

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