ERCC excision repair 6 like, spindle assembly checkpoint helicase

ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase (ERCC6L) is a protein that in humans is encoded by the ERCC6L gene. This protein is also known as PICH (Plk1-interacting checkpoint helicase) and is involved in the cell cycle and mitosis.

Function

ERCC6L is a DNA helicase that plays a crucial role in the maintenance of genome stability. It is involved in the resolution of DNA structures that arise during DNA replication, DNA repair, and recombination. ERCC6L is also involved in the spindle assembly checkpoint, a safety mechanism that ensures the correct segregation of chromosomes during cell division.

Clinical Significance

Mutations in the ERCC6L gene have been associated with various types of cancer, including breast cancer, ovarian cancer, and colorectal cancer. The protein's role in the spindle assembly checkpoint makes it a potential target for cancer therapies.

Research

Research into ERCC6L is ongoing, with studies focusing on its role in cancer development and potential as a therapeutic target. Further understanding of this protein could lead to advancements in cancer treatment and prevention.

See Also

• DNA repair
• Spindle assembly checkpoint
• DNA helicase
• Cell cycle
• Mitosis