Eganoprost

Eganoprost is a synthetic analog of prostaglandins, a group of physiologically active lipid compounds having diverse hormone-like effects in animals. Prostaglandins are derived enzymatically from fatty acids and have important roles in the inflammatory response, vasodilation, and smooth muscle contraction.

Pharmacology

Eganoprost functions primarily as an agonist of the prostaglandin F receptor (FP receptor). By binding to this receptor, Eganoprost mimics the action of natural prostaglandins, leading to various physiological effects. These effects include the modulation of intraocular pressure, making Eganoprost potentially useful in the treatment of glaucoma.

Mechanism of Action

Eganoprost lowers intraocular pressure by increasing the outflow of aqueous humor through the uveoscleral pathway. This is achieved by remodeling the extracellular matrix in the ciliary muscle, which facilitates increased fluid drainage from the eye.

Clinical Uses

Eganoprost is primarily used in the management of glaucoma and ocular hypertension. It is administered as an ophthalmic solution, typically in the form of eye drops. The drug is effective in reducing intraocular pressure, thereby preventing damage to the optic nerve and loss of vision.

Side Effects

Common side effects of Eganoprost include:

• Conjunctival hyperemia
• Eye irritation
• Eyelash growth
• Iris pigmentation changes

Less common but more serious side effects may include:

• Macular edema
• Uveitis

Contraindications

Eganoprost should be used with caution in patients with a history of uveitis or macular edema. It is contraindicated in patients with known hypersensitivity to prostaglandin analogs.

Research and Development

Ongoing research is exploring the potential of Eganoprost in other therapeutic areas, such as cardiovascular disease and reproductive health. Its role in modulating smooth muscle contraction makes it a candidate for further investigation in these fields.

Also see

• Prostaglandin analogs
• Glaucoma treatment
• Ocular pharmacology
• Intraocular pressure

External

• Age-Related Macular Degeneration

• Amblyopia (Lazy Eye)

• Anophthalmia and Microphthalmia

• Astigmatism

B

• Behçet's Disease* Bietti's Crystalline Dystrophy

• Blepharitis* Blepharospasm

C

• Cataracts

• Coloboma

• Color Blindness

• Corneal Conditions

D

• Diabetic Retinopathy

• Dry Eye

F

• Floaters

G

• Glaucoma

I

• Idiopathic Intracranial Hypertension

L

• Low Vision

M

• Macular Edema

• Macular Hole

• Macular Pucker

P

• Pink Eye

R

• Rare Diseases

• Refractive Errors

• Retinal Detachment

• Retinitis Pigmentosa

• Retinoblastoma

• Retinopathy of Prematurity

S

• Stargardt Disease

U

• Usher Syndrome

• Uveitis

V

• Vitreous Detachment