Elastosis perforans serpiginosa

Elastosis perforans serpiginosa (EPS) is a rare skin condition characterized by the elimination of abnormal elastic fibers through the skin. It is classified as a primary perforating dermatosis. That is, a condition where there is transepidermal elimination of dermal material. The condition is often associated with D-penicillamine therapy, Down syndrome, and Ehlers-Danlos syndrome.

Etiology

The exact cause of EPS is unknown. However, it is often associated with certain conditions and medications. These include:

• D-penicillamine therapy
• Down syndrome
• Ehlers-Danlos syndrome

Symptoms

The symptoms of EPS include:

• Red or skin-colored bumps
• Lesions that form a winding pattern
• Itching

Diagnosis

Diagnosis of EPS is primarily based on the clinical appearance of the skin lesions. A skin biopsy may be performed to confirm the diagnosis.

Treatment

Treatment options for EPS include:

• Topical retinoids
• Cryotherapy
• Laser therapy

See also

• List of cutaneous conditions
• Dermatology

References

Elastosis perforans serpiginosa Resources
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