Kyrle disease
Kyrle disease
Kyrle disease, also known as hyperkeratosis follicularis et parafollicularis in cutem penetrans, is a rare skin disorder characterized by the development of large keratotic papules, primarily on the extremities. It was first described by the Austrian dermatologist Josef Kyrle in 1916.
Clinical Presentation[edit | edit source]
Kyrle disease typically presents with hyperkeratotic papules that can range from 1 to 10 mm in diameter. These lesions are often found on the legs, arms, and trunk, and they may be associated with pruritus (itching). The papules are usually skin-colored or brown and have a central keratin plug.
Pathophysiology[edit | edit source]
The exact cause of Kyrle disease is not well understood. It is believed to be related to metabolic disorders such as diabetes mellitus and chronic renal failure. The disease is characterized by the abnormal proliferation of keratinocytes and the formation of keratin plugs that penetrate the epidermis and dermis.
Diagnosis[edit | edit source]
The diagnosis of Kyrle disease is primarily clinical, based on the characteristic appearance of the lesions. A skin biopsy can be performed to confirm the diagnosis, revealing hyperkeratosis, parakeratosis, and the presence of keratin plugs.
Treatment[edit | edit source]
There is no definitive cure for Kyrle disease. Treatment is mainly symptomatic and may include the use of topical keratolytics, such as salicylic acid and urea, to reduce the hyperkeratosis. In some cases, systemic retinoids may be prescribed to help control the proliferation of keratinocytes.
Prognosis[edit | edit source]
The prognosis for Kyrle disease varies. While the condition is chronic and can be persistent, it is generally not life-threatening. The severity of symptoms can fluctuate, and some patients may experience periods of remission.
Related Conditions[edit | edit source]
Kyrle disease is part of a group of disorders known as follicular keratoses, which also includes conditions such as keratosis pilaris and lichen spinulosus.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
 | This dermatology article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
