Endospore

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(Redirected from Endospore-forming bacteria)


Bacillus subtilis endospore
Paenibacillus alvei endospore under a microscope
Diagram of endospore formation
Various bacterial spores

An endospore is a dormant, tough, and non-reproductive structure produced by certain bacteria from the Firmicutes phylum. The primary function of most endospores is to ensure the survival of a bacterium through periods of environmental stress. Endospores are resistant to ultraviolet and gamma radiation, desiccation, lysozyme, temperature, starvation, and chemical disinfectants. They are commonly found in soil and water, where they may survive for long periods of time.

Formation[edit | edit source]

Endospore formation, or sporulation, is a complex process that occurs when a bacterium encounters unfavorable conditions. The process begins with the replication of the bacterium's DNA, followed by the formation of a septum that divides the cell asymmetrically. The smaller compartment, known as the forespore, will become the endospore, while the larger compartment, the mother cell, will eventually lyse and release the mature endospore.

The forespore is engulfed by the mother cell, and a series of protective layers are formed around it. These layers include the cortex, which is made of peptidoglycan, and the spore coat, which is composed of proteins. The core of the endospore contains the bacterium's DNA, ribosomes, and large amounts of dipicolinic acid, which helps stabilize the DNA and proteins.

Resistance[edit | edit source]

Endospores are highly resistant to environmental stresses due to their unique structure. The spore coat provides a physical barrier to chemicals and enzymes, while the cortex helps maintain the spore's dehydration, which is crucial for its resistance to heat and radiation. The presence of dipicolinic acid and calcium ions in the core also contributes to the endospore's resistance by stabilizing the DNA and proteins.

Germination[edit | edit source]

When favorable conditions return, endospores can germinate and return to their vegetative state. Germination involves the uptake of water, swelling of the spore, and the breakdown of the spore coat. The bacterium then resumes normal metabolic activity and growth.

Significance[edit | edit source]

Endospores are of great significance in the medical and food industries due to their resistance to sterilization methods. They can survive in extreme conditions that would kill most vegetative cells, making them a challenge to eliminate. This resistance is particularly important in the context of Clostridium botulinum, the bacterium responsible for botulism, and Bacillus anthracis, the causative agent of anthrax.

Also see[edit | edit source]




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