Estradiol 17β-acetate
Estradiol 17β-acetate is a synthetic ester of the natural hormone estradiol, a form of estrogen. It is used in hormone replacement therapy and other medical applications to treat symptoms associated with menopause, hypogonadism, and other conditions related to estrogen deficiency.
Chemical Structure and Properties[edit | edit source]
Estradiol 17β-acetate is chemically known as the acetate ester of estradiol. Its molecular formula is C20H26O3, and it has a molecular weight of 314.42 g/mol. The compound is characterized by the presence of an acetate group at the 17β position of the estradiol molecule, which enhances its stability and bioavailability.
Pharmacology[edit | edit source]
Estradiol 17β-acetate functions by binding to and activating the estrogen receptors in various tissues, including the reproductive system, bone, and cardiovascular system. This activation leads to the modulation of gene expression and the regulation of various physiological processes.
Medical Uses[edit | edit source]
Estradiol 17β-acetate is primarily used in:
- Hormone replacement therapy (HRT) for menopausal symptoms such as hot flashes, vaginal atrophy, and osteoporosis.
- Treatment of hypogonadism in women, where the body produces insufficient amounts of estrogen.
- Management of certain types of breast cancer and prostate cancer.
Administration and Dosage[edit | edit source]
Estradiol 17β-acetate can be administered orally, transdermally, or via intramuscular injection. The dosage and administration route depend on the specific condition being treated and the patient's response to therapy.
Side Effects[edit | edit source]
Common side effects of estradiol 17β-acetate include:
Serious side effects may include an increased risk of thromboembolism, stroke, and certain types of cancer.
Contraindications[edit | edit source]
Estradiol 17β-acetate is contraindicated in individuals with:
- Known or suspected breast cancer
- Active or history of thromboembolic disorders
- Liver disease
- Known hypersensitivity to estradiol or any of its components
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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