Estradiol benzoate butyrate

Estradiol benzoate butyrate (EBB) is a synthetic, steroidal estrogen that is used in hormone therapy. It is a combined ester of estradiol, benzoic acid, and butyric acid, and is marketed in Europe and elsewhere worldwide.

Pharmacology

EBB acts as a prodrug to estradiol, and hence is considered to be a natural and bioidentical form of estrogen. Upon administration, it is stored in adipose tissue and slowly released over a period of several days. EBB is converted into estradiol in the body, which is the main and most biologically active form of estrogen in the body.

Medical uses

EBB is used in hormone therapy for menopausal symptoms and low estrogen levels in women, and in hormone therapy for transgender women. It has also been used to treat prostate cancer in men.

Side effects

Like all estrogens, EBB has the potential to cause a number of side effects, including nausea, bloating, breast tenderness, and an increased risk of certain types of cancer.

See also

• List of estrogen esters
• Estradiol benzoate
• Estradiol butyrate

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