Estradiol decanoate

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Estradiol decanoate is a synthetic, steroidal estrogen and an estrogen ester – specifically, the C17β decanoate (decylate) ester of estradiol. It is used in hormone replacement therapy (HRT) for menopausal symptoms and in hormonal contraception.

Pharmacology

Estradiol decanoate is a prodrug of estradiol, meaning it is converted into estradiol in the body. It is administered via intramuscular injection, where it is slowly released and converted into estradiol, providing a prolonged duration of action. This makes it suitable for use in long-term hormone therapy.

Medical Uses

Estradiol decanoate is primarily used in hormone replacement therapy for the treatment of symptoms associated with menopause, such as hot flashes, vaginal atrophy, and osteoporosis. It is also used in hormonal contraception in combination with progestins.

Side Effects

The side effects of estradiol decanoate are similar to those of other estrogens and may include nausea, breast tenderness, headache, and fluid retention. Long-term use of estrogens has been associated with an increased risk of endometrial cancer, breast cancer, and cardiovascular disease.

Chemistry

Estradiol decanoate is a steroidal estrogen ester. Its chemical structure is characterized by the presence of a decanoate ester group at the C17β position of the estradiol molecule. This modification increases the lipophilicity of the molecule, allowing for a slower release and prolonged duration of action when administered via intramuscular injection.

History

Estradiol decanoate was first introduced in the 1950s and has been used in various formulations for hormone therapy and contraception. It has been studied extensively for its pharmacokinetics and clinical efficacy.

See Also

• Estradiol
• Hormone replacement therapy
• Hormonal contraception
• Estrogen