Estradiol diundecylate

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Estradiol diundecylate is a synthetic, steroidal estrogen and an estrogen ester – specifically, the C17β undecylate ester of estradiol. It is used in hormone replacement therapy for menopausal symptoms and in hormonal contraception.

Pharmacology

Estradiol diundecylate is a prodrug of estradiol, meaning it is converted into estradiol in the body. It is administered via intramuscular injection, where it is slowly released and converted into estradiol, providing a prolonged duration of action.

Medical Uses

Estradiol diundecylate is used in hormone replacement therapy to treat symptoms of menopause such as hot flashes, vaginal atrophy, and osteoporosis. It is also used in hormonal contraception in combination with progestins.

Side Effects

The side effects of estradiol diundecylate are similar to those of other estrogens and may include nausea, breast tenderness, headache, and fluid retention. Long-term use of estrogens has been associated with an increased risk of endometrial cancer, breast cancer, and cardiovascular disease.

Chemistry

Estradiol diundecylate is a synthetic estradiol ester. Its chemical structure is characterized by the presence of two undecylate groups attached to the C17β position of the estradiol molecule.

See Also

• Estradiol
• Estrogen
• Hormone replacement therapy
• Hormonal contraception