Extracellular adenylate cyclase

Extracellular adenylate cyclase
Identifiers
EC number	4.6.1.1
CAS number	9012-42-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Extracellular adenylate cyclase is an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) and pyrophosphate. It is a type of adenylate cyclase that is located outside the cell, unlike most adenylate cyclase enzymes which are typically found on the inner side of the cell membrane. This enzyme plays a crucial role in various biological processes, including cell signaling, neurotransmission, and hormone response.

Function

Extracellular adenylate cyclase functions by catalyzing the synthesis of cAMP, a critical second messenger in cellular signaling pathways. cAMP is involved in the regulation of a wide range of biological processes, such as gene expression, metabolism, and cell proliferation. By producing cAMP outside the cell, extracellular adenylate cyclase can influence nearby cells in a paracrine manner, affecting their behavior and physiological responses.

Structure

The structure of extracellular adenylate cyclase is distinct from its intracellular counterparts. It is typically anchored to the cell membrane, with its active site exposed to the extracellular environment. This positioning allows it to access ATP in the extracellular space and produce cAMP that can readily diffuse to nearby cells.

Biological Significance

Extracellular adenylate cyclase has been implicated in various physiological and pathological processes. For example, it plays a role in the immune response by modulating the activity of immune cells through cAMP-dependent pathways. Additionally, it has been studied for its involvement in the development of certain diseases, where abnormal cAMP signaling is a factor.

Clinical Relevance

Understanding the function and regulation of extracellular adenylate cyclase can lead to new therapeutic targets for diseases where cAMP signaling is disrupted. Modulators of this enzyme could potentially be used to treat conditions such as heart disease, diabetes, and certain types of cancer.

Research

Research on extracellular adenylate cyclase involves exploring its role in disease mechanisms and its potential as a target for drug development. Studies typically focus on how altering the activity of this enzyme affects cellular processes and disease outcomes.