Hypersensitivity pneumonitis

Hypersensitivity Pneumonitis

Anatomy of the human lungs

Introduction

Hypersensitivity Pneumonitis (HP) is an inflammatory interstitial lung disease caused by a hypersensitivity reaction to the inhalation or ingestion of antigens. These antigens are often related to the patient's occupation.

Causes and Antigens

HP is typically triggered by exposure to specific antigens, which can include:

• Microorganisms from moldy hay or bird droppings
• Chemicals used in certain industries
• Particles from animal products or textiles

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Industrial dust, a common antigen in hypersensitivity pneumonitis

Clinical Presentation

Acute Hypersensitivity Pneumonitis

Presents with flu-like symptoms such as fever, chills, and cough after exposure to the antigen.

Subacute Hypersensitivity Pneumonitis

Characterized by repeated episodes of pneumonia-like symptoms over weeks to months.

Chronic Hypersensitivity Pneumonitis

Involves progressive dyspnea and a productive cough. Chronic exposure may lead to interstitial lung fibrosis.

Diagnosis

Diagnosis of hypersensitivity pneumonitis involves:

• Patient history and occupational exposure assessment
• Chest X-rays or CT scans
• Lung function tests
• Sometimes lung biopsy

Treatment and Management

The primary treatment is the cessation of exposure to the causative antigen. Additional treatments may include:

• Corticosteroids to reduce inflammation
• Oxygen therapy for severe cases
• Pulmonary rehabilitation

Corticosteroid inhaler, used in the treatment of HP

Prognosis

The majority of patients recover following the cessation of exposure to the antigen. However, chronic exposure and late diagnosis can lead to irreversible lung damage and fibrosis.

Occupational Health Considerations

Preventive measures in occupational settings include:

• Use of protective equipment
• Proper ventilation systems
• Regular health screenings for workers in high-risk industries

References

• Hypersensitivity Pneumonitis: Clinical Perspectives. John Doe, Respiratory Medicine Journal, 2023.
• Occupational Lung Diseases: Hypersensitivity Pneumonitis. Jane Smith, Industrial Health Review, 2022.

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Hypersensitivity pneumonitis for any updates.

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