Estradiol acetate

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Estradiol acetate is a synthetic estrogen that is used in hormone replacement therapy (HRT) and for the treatment of menopausal symptoms. It is a prodrug of estradiol, the primary female sex hormone, and is converted into estradiol in the body.

Pharmacology[edit | edit source]

Estradiol acetate is a prodrug of estradiol, meaning it is metabolized into estradiol in the body. It is administered orally, and has a longer half-life than estradiol, allowing for less frequent dosing. The conversion of estradiol acetate to estradiol occurs in the liver.

Clinical use[edit | edit source]

Estradiol acetate is used primarily in hormone replacement therapy for menopausal women. It helps to alleviate symptoms of menopause, such as hot flashes and vaginal dryness. In addition, it is used in the treatment of hypoestrogenism, a condition characterized by low levels of estrogen in the body.

Side effects[edit | edit source]

Like all medications, estradiol acetate can cause side effects. The most common side effects include nausea, vomiting, bloating, stomach cramps, changes in weight, changes in menstrual periods, and headache. More serious side effects can include breast lumps, mental/mood changes, severe stomach/abdominal pain, unusual vaginal bleeding, and dark urine.

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