GBR-12,935

GBR-12935 is a psychoactive drug and research chemical widely used in scientific studies. It acts primarily as a potent and selective dopamine reuptake inhibitor, with a particular focus on the dopamine transporter (DAT). GBR-12935 has been instrumental in the study of dopamine system disorders, such as Parkinson's disease, schizophrenia, and drug addiction.

Chemistry

GBR-12935 belongs to the phenyltropane class of compounds, which are known for their stimulant and anorectic properties. Its chemical structure is similar to that of cocaine, although its pharmacological profile is significantly different, primarily due to its selectivity for the dopamine transporter.

Pharmacology

The primary mechanism of action of GBR-12935 is the inhibition of dopamine reuptake. By binding to the dopamine transporter, GBR-12935 prevents the reabsorption of dopamine into the presynaptic neuron, leading to an increase in dopamine levels in the synaptic cleft. This increase in extracellular dopamine concentrations can significantly affect mood, motivation, and movement, which is why GBR-12935 is of particular interest in the study of dopamine-related disorders.

Research Uses

GBR-12935 has been extensively used in research to understand the role of the dopamine transporter in various neurological and psychiatric conditions. It has also been used as a tool to investigate the effects of increased synaptic dopamine levels. Due to its high selectivity for the dopamine transporter, GBR-12935 is a valuable compound in the development of potential therapeutic agents for the treatment of conditions such as depression, Parkinson's disease, and drug addiction.

Legal Status

The legal status of GBR-12935 varies by country, but it is primarily considered a research chemical and is not approved for medical use or recreational consumption. Its possession and distribution are regulated in many jurisdictions due to its psychoactive properties and potential for abuse.

See Also

• Dopamine
• Dopamine transporter
• Psychoactive drug
• Phenyltropane