GDF3
GDF3 (Growth Differentiation Factor 3) is a protein that in humans is encoded by the GDF3 gene. It is a member of the TGF-beta superfamily of growth and differentiation factors.
Function[edit | edit source]
GDF3 is a secreted ligand of the TGF-beta (Transforming Growth Factor-beta) family, which has important roles in the formation of the embryo and in adult tissue homeostasis. It is expressed in various tissues, with high levels in the placenta and lower levels in the kidney and pancreas.
Clinical significance[edit | edit source]
Mutations in the GDF3 gene have been associated with various diseases, including cancer, diabetes, and obesity. It has also been implicated in the development of congenital heart defects and eye diseases.
Research[edit | edit source]
Research into GDF3 has focused on its role in stem cell differentiation and regenerative medicine. It has been found to be a key regulator of pluripotency in embryonic stem cells.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- GDF3 at the US National Library of Medicine Medical Subject Headings (MeSH)
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
