GPR119
GPR119 is a G protein-coupled receptor that is expressed in various tissues, including the pancreas and the gastrointestinal tract. It is involved in the regulation of glucose homeostasis and lipid metabolism.
Function[edit | edit source]
GPR119 is activated by oleoylethanolamide, a naturally occurring bioactive lipid that has been shown to increase the secretion of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These incretin hormones are released from the intestines and stimulate insulin secretion from the pancreas in a glucose-dependent manner.
Therapeutic potential[edit | edit source]
Due to its role in glucose homeostasis and lipid metabolism, GPR119 is considered a potential therapeutic target for the treatment of type 2 diabetes and related metabolic disorders. Several GPR119 agonists have been developed and tested in clinical trials, but none have yet been approved for clinical use.
See also[edit | edit source]
- G protein-coupled receptor
- Glucagon-like peptide-1
- Glucose-dependent insulinotropic peptide
- Type 2 diabetes
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