GW-9662

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Overview[edit | edit source]

GW-9662 is a synthetic chemical compound that acts as a selective antagonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It is primarily used in scientific research to study the role of PPARγ in various biological processes, including metabolism, inflammation, and cancer.

Chemical Structure and Properties[edit | edit source]

GW-9662 is chemically known as 2-chloro-5-nitro-N-phenylbenzamide. It is characterized by its aromatic benzamide structure, which includes a nitro group and a chlorine atom that contribute to its activity as a PPARγ antagonist. The molecular formula of GW-9662 is C13H9ClN2O3, and it has a molecular weight of 276.68 g/mol.

Mechanism of Action[edit | edit source]

GW-9662 functions by binding to the ligand-binding domain of PPARγ, thereby inhibiting its activity. PPARγ is a nuclear receptor that regulates the expression of genes involved in glucose and lipid metabolism, adipocyte differentiation, and inflammation. By blocking PPARγ, GW-9662 can modulate these pathways, making it a valuable tool for studying metabolic diseases and inflammatory conditions.

Applications in Research[edit | edit source]

GW-9662 is widely used in preclinical studies to investigate the role of PPARγ in various diseases. Some of the key areas of research include:

  • Metabolic Disorders: GW-9662 is used to study the effects of PPARγ inhibition on insulin sensitivity, glucose homeostasis, and lipid metabolism, providing insights into conditions such as type 2 diabetes and obesity.
  • Cancer: The compound is also employed in cancer research to understand the role of PPARγ in tumorigenesis and cancer progression, particularly in breast cancer and colon cancer.

Safety and Handling[edit | edit source]

As with many research chemicals, GW-9662 should be handled with care. It is important to follow appropriate safety protocols, including the use of personal protective equipment and working in a well-ventilated area. The compound should be stored in a cool, dry place, away from light and moisture.

Also see[edit | edit source]

References[edit | edit source]



External Links[edit | edit source]


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