Gadofosveset trisodium

From WikiMD's Wellness Encyclopedia

What is Gadofosveset trisodium?[edit | edit source]


Gadofosveset skeletal



What are the uses of this medicine?[edit | edit source]


How does this medicine work?[edit | edit source]

  • Following intravenous injection, gadofosveset binds reversibly to endogenous serum albumin resulting in longer vascular residence time than non-protein binding contrast agents.
  • The binding to serum albumin also increases the magnetic resonance relaxivity of gadofosveset and decreases the relaxation time (T1)
  • of water protons resulting in an increase in signal intensity (brightness) of blood.


Who Should Not Use this medicine ?[edit | edit source]

This medicine cannot be used in patients with:


What drug interactions can this medicine cause?[edit | edit source]

  • No drug interaction reactions were observed in clinical trials.
  • Consider the possibility of Vasovist, Ablavar interaction with concomitantly administered medications that bind to albumin.


Is this medicine FDA approved?[edit | edit source]

  • Initial U.S. Approval: 2008


How should this medicine be used?[edit | edit source]

Recommended dosage:

  • Administer C Injection by an intravenous bolus, manually or by power injection, at a dose of 0.12 mL/kg body weight (0.03 mmol/kg) over a period of time up to 30 seconds followed by a 25-30 mL normal saline flush.
  • Imaging is performed in two stages, the dynamic stage which begins immediately following Vasovist, Ablavar Injection and the steady-state stage, which begins following dynamic imaging; generally 5 to 7 minutes after Vasovist, Ablavar Injection.

Administration:

  • Administer Vasovist, Ablavar Injection by an intravenous bolus, manually or by power injection.


What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • VASOVIST Injection contains 244 mg gadofosveset trisodium (equivalent to 0.25 mmol/mL) and is available in single-use vials.
  • ABLAVAR Injection contains 244 mg gadofosveset trisodium (equivalent to 0.25 mmol/mL) and is available in single-use vials.

This medicine is available in fallowing brand namesː

  • Vasovist, Ablavar


What side effects can this medication cause?[edit | edit source]

The most common side effects of this medicine include:


What special precautions should I follow?[edit | edit source]

  • Nephrogenic Systemic Fibrosis may result from administration of gadolinium-based contrast agents to certain patients. Higher than recommended dosing or repeated dosing appears to increase the risk.
  • Hypersensitivity reactions, including anaphylactoid and/or anaphylactic reactions may result from Vasovist, Ablavar administration. Assess patients for a history of allergic reactions to gadolinium-based contrast agents and monitor patients closely for need of emergency cardiorespiratory support.
  • Gadolinium-based contrast agents, including Vasovist, Ablavar may increase the risk for acute renal failure in patients with a history of renal insufficiency.
  • QTc prolongation has been reported following Vasovist, Ablavar administration. Assess patients for a history of underlying conditions that may predispose to arrhythmias due to QTc prolongation.


What to do in case of emergency/overdose?[edit | edit source]

Symptoms of overdosage may include:

  • No Vasovist, Ablavar overdoses were reported in clinical trials.

Management of overdosage:

  • In the event of an overdose, direct treatment toward the support of all vital functions and prompt institution of symptomatic therapy.
  • Gadofosveset has been shown to be removed by hemodialysis using a high flux dialysis procedure.


Can this medicine be used in pregnancy?[edit | edit source]

  • There are no adequate and well-controlled studies of Vasovist, Ablavar in pregnant women.


Can this medicine be used in children?[edit | edit source]

  • The safety and effectiveness of Vasovist, Ablavar in patients under 18 years of age have not been established.


What are the active and inactive ingredients in this medicine?[edit | edit source]

Active ingredient:

  • gadofosveset trisodium

Inactive ingredients:

  • fosveset
  • water


Who manufactures and distributes this medicine?[edit | edit source]

Vasovist:

Ablavar:


What should I know about storage and disposal of this medication?[edit | edit source]

  • Store Vasovist, Ablavar Injection at 25°C (77°F: excursions permitted to 15 to 30°C [59 to 86°F]).
  • Protect from light and freezing.


Gadofosveset trisodium Resources
Wikipedia


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Deepika vegiraju