Galanin receptor 1
Galanin receptor 1 (GALR1) is a G protein-coupled receptor that in humans is encoded by the GALR1 gene. It is one of the three known receptors of the neuropeptide galanin.
Function[edit | edit source]
Galanin receptor 1 is a member of the galanin receptor subfamily of G protein-coupled receptors, which also includes GALR2 and GALR3. The galanin receptors are activated by the neuropeptide galanin and have been implicated in a variety of biological processes, including pain perception, memory, depression, and feeding behavior.
Structure[edit | edit source]
Like other G protein-coupled receptors, GALR1 is characterized by seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. The gene encoding GALR1 is located on chromosome 18 in humans.
Clinical significance[edit | edit source]
Alterations in galanin receptor 1 function have been associated with a number of pathological conditions, including neuropathic pain, epilepsy, depression, and Alzheimer's disease. In addition, galanin and its receptors are thought to play a role in the regulation of food intake and body weight, and alterations in their function may contribute to obesity and type 2 diabetes.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- Galanin Receptor 1 at the IUPHAR Database
This GPCR-related article is a stub. You can help WikiMD by expanding it.
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