Galanin receptor 1

Galanin receptor 1 (GALR1) is a G protein-coupled receptor that in humans is encoded by the GALR1 gene. It is one of the three known receptors of the neuropeptide galanin.

Function

Galanin receptor 1 is a member of the galanin receptor subfamily of G protein-coupled receptors, which also includes GALR2 and GALR3. The galanin receptors are activated by the neuropeptide galanin and have been implicated in a variety of biological processes, including pain perception, memory, depression, and feeding behavior.

Structure

Like other G protein-coupled receptors, GALR1 is characterized by seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. The gene encoding GALR1 is located on chromosome 18 in humans.

Clinical significance

Alterations in galanin receptor 1 function have been associated with a number of pathological conditions, including neuropathic pain, epilepsy, depression, and Alzheimer's disease. In addition, galanin and its receptors are thought to play a role in the regulation of food intake and body weight, and alterations in their function may contribute to obesity and type 2 diabetes.

See also

• Galanin
• Galanin receptor
• Galanin receptor 2
• Galanin receptor 3

External links

• Galanin Receptor 1 at the IUPHAR Database

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