Galanin receptor 3
Galanin receptor 3 (GALR3) is a G protein-coupled receptor that in humans is encoded by the GALR3 gene. It is one of the three known receptors of the neuropeptide galanin.
Function[edit | edit source]
Galanin receptor 3 is a member of the galanin family of G protein-coupled receptors, which also includes GALR1 and GALR2. These receptors are activated by the neuropeptide galanin and have been implicated in a variety of biological processes, including pain perception, memory and learning, neuroendocrine regulation, and depression.
Gene[edit | edit source]
The GALR3 gene is located on the chromosome 22 at position 22q13.1. It spans approximately 5.5 kilobases and consists of three exons. The gene is expressed in various tissues, including the brain, pituitary gland, small intestine, and colon.
Clinical significance[edit | edit source]
Alterations in the function of the galanin system, including GALR3, have been implicated in several neurological disorders, such as Alzheimer's disease, epilepsy, and depression. In addition, galanin and its receptors are involved in the regulation of food intake, and alterations in their function may contribute to obesity and type 2 diabetes.
Pharmacology[edit | edit source]
Several drugs that target the galanin system, including GALR3, are under development for the treatment of various disorders, including depression, anxiety, Alzheimer's disease, and pain. These drugs include galanin agonists, which activate the galanin receptors, and galanin antagonists, which block their function.
See also[edit | edit source]
References[edit | edit source]
This GPCR-related article is a stub. You can help WikiMD by expanding it.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD