HDGC

HDGC (Hereditary Diffuse Gastric Cancer) is a genetic disorder that increases the risk of developing stomach cancer. It is caused by mutations in the CDH1 gene.

Overview[edit | edit source]

Hereditary Diffuse Gastric Cancer (HDGC) is a type of stomach cancer that is passed down through families. This condition greatly increases the risk of developing diffuse gastric cancer, a specific type of stomach cancer that starts in the cells lining the stomach and spreads throughout the stomach.

Causes[edit | edit source]

HDGC is caused by mutations in the CDH1 gene. This gene provides instructions for making a protein that helps cells stick together and remain in the correct location in tissues and organs. Mutations in the CDH1 gene disrupt the function of this protein, which can lead to the development of diffuse gastric cancer.

Symptoms[edit | edit source]

The symptoms of HDGC can vary, but they often include:

Diagnosis[edit | edit source]

HDGC is diagnosed through a combination of genetic testing, endoscopy, and biopsy. Genetic testing can identify mutations in the CDH1 gene, while endoscopy and biopsy can confirm the presence of cancer in the stomach.

Treatment[edit | edit source]

The treatment for HDGC typically involves surgery to remove the stomach (gastrectomy). This is because the cancer is often widespread throughout the stomach, making it difficult to remove through less invasive methods. Other treatments, such as chemotherapy and radiation therapy, may also be used.

References[edit | edit source]

HDGC Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.