HLA-DQA2

HLA-DQA2 is a gene that provides instructions for making a protein that plays a critical role in the immune system. The HLA-DQA2 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

Function

The HLA-DQA2 gene belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Clinical significance

Variations in the HLA-DQA2 gene have been associated with susceptibility to certain autoimmune diseases, including rheumatoid arthritis and type 1 diabetes. Further research is needed to confirm these associations and to understand how variations in the HLA-DQA2 gene influence the risk of developing these diseases.

See also

• Human leukocyte antigen
• HLA-DQ
• Autoimmune disease

External links

• HLA-DQA2 at NCBI

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