HOXB2
HOXB2 is a gene that in humans is encoded by the HOXB2 protein. This gene is part of the homeobox gene family, which are critical in the formation and development of the body plan of an organism during embryogenesis.
Function[edit | edit source]
The HOXB2 gene is a member of the Antennapedia class of homeotic genes, which are involved in the regulation of body structure development. The protein encoded by this gene is a transcription factor that likely plays a role in neuron differentiation.
Clinical Significance[edit | edit source]
Mutations in the HOXB2 gene have been associated with several congenital disorders, including syndromes affecting the craniofacial region. Research is ongoing to further understand the role of this gene in human health and disease.
Structure[edit | edit source]
The HOXB2 gene is located on the short (p) arm of chromosome 17 at position 21.32. The gene spans approximately 3,000 base pairs and contains two exons. The encoded protein is 338 amino acids in length.
Expression[edit | edit source]
HOXB2 is expressed in various tissues during embryonic development, including the central nervous system, spinal cord, and hindbrain. In adults, expression is typically limited to certain regions of the brain.
See Also[edit | edit source]
References[edit | edit source]
Genes on human chromosome 17 | ||||||
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This human genetics related article is a stub.
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